Tennessee Titans

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San Francisco 49ers

San Francisco 49ers vs Tennessee Titans — Game Preview, Stats & Players to Watch

A key NFL contest features the San Francisco 49ers hosting the Tennessee Titans in what could be a showcase of contrasting styles and momentum heading into mid‑December.

Game Details

• Date: 2025-12-14
• Kick-off: 4:25 p.m. (ET)
• Venue: Levi’s Stadium, Santa Clara, California
• Broadcast: FOX, Fox Sports App, Fubo Sports, NFL+

Recent Form & Key Storylines

San Francisco enters this matchup buoyed by a strong run of play, while Tennessee has struggled to find consistency in their recent outings. The Titans' defense has shown vulnerabilities against explosive offenses, whereas San Francisco’s balanced attack continues to pose challenges for opponents. Head‑to‑head between these two has featured tight, physical battles in recent years, adding intrigue to this encounter. No confirmed absences or injuries publicly verified within the last 60 days are affecting top-tier players on either roster.

Summary Stats

• San Francisco 49ers last 5: W‑W‑W‑L‑W
• Tennessee Titans last 5: W‑L‑L‑L‑L
• Last head‑to‑head: In their most recent meeting, the 49ers edged the Titans in a close, defensively charged game.

Players to Watch

The 49ers’ dynamic playmaker, who has consistently impacted both the pass rush and run defense, remains a central figure in shaping game flow. On the Titans’ side, a key offensive weapon has emerged as a focal point of their scoring efforts and will test San Francisco’s secondary under pressure.